Recent advances in stem cell biology have created new opportunities to study developmental and disease processes as they occur in the complex microenvironments exhibited by oral mucosa and skin. Our laboratory is developing experimental approaches to derive mesenchymal and epithelial cell types from induced pluripotent stem cells (iPSC). Our ultimate goal is to use these cells for personalized therapies for regeneration and repair of diseased or damaged tissues and organs. We continue to develop and apply novel 3D, human bioengineered tissues that provide powerful platforms that closely mimic the form and function of human tissues and organs. We view 3D tissues harboring a broad spectrum of stem cells as a powerful translational platform that can determine how iPSC-derived cells behave in an in vivo-like microenvironment. We hope that our research will allow us to develop, test and apply a spectrum of new and powerful therapies for oral and skin diseases.